Huntington is a city in Cabell and Wayne counties in the U.S. state of West Virginia. It is the county seat of Cabell County, and the largest city in the Huntington–Ashland metropolitan area, sometimes referred to as the Tri-State Area. A historic and bustling city of commerce and heavy industry, Huntington has benefited from its location on the Ohio River at the mouth of the Guyandotte River.

It is home to the Port of Huntington Tri-State, the second-busiest inland port in the United States. As of the 2020 census, its metro area is the largest in West Virginia, spanning seven counties across three states and having a population of 359,862. Huntington is the second-largest city in West Virginia, with a population of 46,842 at the 2020 census.

Both the city and metropolitan area declined in population from the 2010 census, a trend that has been ongoing for six decades as Huntington has lost over 40,000 residents in that time frame. Surrounded by extensive natural resources, the industrial sector is based in coal, oil, chemicals and steel, all of which support Huntington's diversified economy.

The city is a vital rail-to-river transfer point for the marine transportation industry. Also, it is considered a scenic locale in the western foothills of the Appalachian Mountains. Its location was selected as ideal for the western terminus of the Chesapeake and Ohio Railway, the predecessor of what would become CSX Transportation which still operates CSX Transportation-Huntington Division in the city to date.

The railroad founded Huntington as one of the nation's first planned communities to facilitate the railroad and other transportation-related industries at the railway's western terminus. The site, previously a collection of agricultural homesteads, developed fast after the railroad's completion in 1871 and is eponymously named for the railroad company's founder, Collis Potter Huntington.

The first identifiable permanent settlement, Holderby's Landing, was founded in 1775 in the Colony of Virginia. With the exception of the neighborhoods of Westmoreland and Spring Valley, most of the city is in Cabell County.The city is the home of Marshall University as well as the Huntington Museum of Art; the Mountain Health Arena; the U.S.

Army Corps of Engineers (Huntington District); the Collis P. Huntington Historical Society and Railroad Museum; Camden Park, one of the world's oldest amusement parks; the headquarters of the CSX Transportation-Huntington Division, the largest division in the CSX network; the Special Metals Plant; and the Port of Huntington Tri-State, the largest river port in the United States.

The largest employers are Marshall University, Cabell Huntington Hospital, St. Mary's Medical Center, CSX Transportation, the U.S. Army Corps of Engineers, Amazon, DirecTV, and the City of Huntington.